解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Here, we demonstrate the use of pump-probe microscopy for high-resolution studies of vermilion degradation. Vermilion (mostly α-HgS), an important red pigment used in historical paintings, blackens over time, and metallic Hg and β-HgS have been implicated as possible degradation products. Conventional analysis techniq...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw3136
更新日期:2019-06-21 00:00:00
abstract::Superomniphobic textures are at the frontier of surface design for vast arrays of applications. Despite recent substantial advances in fabrication methods for reentrant and doubly reentrant microstructures, design optimization remains a major challenge. We overcome this in two stages. First, we develop readily general...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav7328
更新日期:2019-06-21 00:00:00
abstract::One of the most plausible scenarios of the origin of life assumes the preceding prebiotic autotrophic metabolism in sulfide-rich hydrothermal vent environments. However, geochemical mechanisms to harness the reductive power provided by hydrothermal systems remain to be elucidated. Here, we show that, under a geoelectr...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav7848
更新日期:2019-06-19 00:00:00
abstract::Many applications in modern technology, such as self-cleaning surfaces and digital microfluidics, require control over individual fluid droplets on flat surfaces. Existing techniques may suffer from side effects resulting from high electric fields and high temperatures. Here, we introduce a markedly different method, ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw0914
更新日期:2019-06-14 00:00:00
abstract::The wiring of vertebrate and invertebrate brains provides the anatomical skeleton for cognition and behavior. Connections among brain regions are characterized by heterogeneous strength that is parsimoniously described by the wiring cost and homophily principles. Moreover, brains exhibit a characteristic global networ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav9694
更新日期:2019-06-12 00:00:00
abstract::Preventing the degradation of metal perovskite solar cells (PSCs) by humid air poses a substantial challenge for their future deployment. We introduce here a two-dimensional (2D) A2PbI4 perovskite layer using pentafluorophenylethylammonium (FEA) as a fluoroarene cation inserted between the 3D light-harvesting perovski...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw2543
更新日期:2019-06-07 00:00:00
abstract::SN2-type halide substitution and hydrolysis are two of the most ubiquitous reactions in chemistry. The interplay between these processes is fundamental in atmospheric chemistry through reactions of N2O5 and seawater. N2O5 plays a major role in regulating levels of O3, OH, NO x ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav6503
更新日期:2019-06-05 00:00:00
abstract::Metabolic engineering uses enzymes to produce small molecules with industrial, pharmaceutical, and energy applications. However, efforts to optimize enzymatic pathways for commercial production are limited by the throughput of assays for quantifying metabolic intermediates and end products. We developed a multiplexed ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw9180
更新日期:2019-06-05 00:00:00
abstract::Hybrid organic-inorganic halide perovskites have shown remarkable optoelectronic properties, exhibiting an impressive tolerance to defects believed to originate from correlated motion of charge carriers and the polar lattice forming large polarons. Few experimental techniques are capable of directly probing these corr...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw5558
更新日期:2019-05-31 00:00:00
abstract::Since its domestication in the Fertile Crescent ~8000 to 10,000 years ago, wheat has undergone a complex history of spread, adaptation, and selection. To get better insights into the wheat phylogeography and genetic diversity, we describe allele distribution through time using a set of 4506 landraces and cultivars ori...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav0536
更新日期:2019-05-29 00:00:00
abstract::Noble metal foams (NMFs) are a new class of functional materials featuring properties of both noble metals and monolithic porous materials, providing impressive prospects in diverse fields. Among reported synthetic methods, the sol-gel approach manifests overwhelming advantages for versatile synthesis of nanostructure...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw4590
更新日期:2019-05-24 00:00:00
abstract::The ability of cytosolic lipopolysaccharide (LPS) to activate caspase-11-dependent nonclassical inflammasome is intricately controlled to avoid excessive inflammatory responses. However, very little is known about the regulatory role of various metabolic pathways in the control of caspase-11 activation. Here, we demon...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav5562
更新日期:2019-05-22 00:00:00
abstract::An understanding of the normal state in the high-temperature superconducting cuprates is crucial to the ultimate understanding of the long-standing problem of the origin of the superconductivity itself. This so-called "strange metal" state is thought to be associated with a quantum critical point (QCP) hidden beneath ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav6753
更新日期:2019-05-17 00:00:00
abstract::Traumatic spinal cord injury (SCI) brings numerous inflammatory cells, including macrophages, from the circulating blood to lesions, but pathophysiological impact resulting from spatiotemporal dynamics of macrophages is unknown. Here, we show that macrophages centripetally migrate toward the lesion epicenter after inf...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav5086
更新日期:2019-05-15 00:00:00
abstract::Plasmonic metasurfaces are a promising route for flat panel display applications due to their full color gamut and high spatial resolution. However, this plasmonic coloration cannot be readily tuned and requires expensive lithographic techniques. Here, we present scalable electrically driven color-changing metasurface...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw2205
更新日期:2019-05-10 00:00:00
abstract::Humans and animals have a "number sense," an innate capability to intuitively assess the number of visual items in a set, its numerosity. This capability implies that mechanisms to extract numerosity indwell the brain's visual system, which is primarily concerned with visual object recognition. Here, we show that netw...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav7903
更新日期:2019-05-08 00:00:00
abstract::Pathological cardiac hypertrophy eventually leads to heart failure without adequate treatment. The immunoproteasome is an inducible form of the proteasome that is intimately involved in inflammatory diseases. Here, we found that the expression and activity of immunoproteasome catalytic subunit β5i were significantly u...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau0495
更新日期:2019-05-08 00:00:00
abstract::Energy band engineering is of fundamental importance in nanoelectronics. Compared to chemical approaches such as doping and surface functionalization, electrical and optical methods provide greater flexibility that enables continuous, reversible, and in situ band tuning on electronic devices of various kinds. In this ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav3430
更新日期:2019-05-03 00:00:00
abstract::The transcription factor p63 is a key mediator of epidermal development. Point mutations in p63 in patients lead to developmental defects, including orofacial clefting. To date, knowledge on how pivotal the role of p63 is in human craniofacial development is limited. Using an inducible transdifferentiation model, comb...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw0946
更新日期:2019-05-01 00:00:00
abstract::Plants produce a myriad of taxonomically restricted specialized metabolites. This diversity-and our ability to correlate genotype with phenotype-makes the evolution of these ecologically and medicinally important compounds interesting and experimentally tractable. Trichomes of tomato and other nightshade family plants...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw3754
更新日期:2019-04-24 00:00:00
abstract::Cancer cells often encounter oxidative stress. However, it is unclear whether normal and cancer cells differentially respond to oxidative stress. Here, we demonstrated that under oxidative stress, hepatocellular carcinoma (HCC) cells exhibit increased antioxidative response and survival rates compared to normal hepato...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav4570
更新日期:2019-04-24 00:00:00
abstract::We have developed a way to map brain-wide networks using focal pulsed infrared neural stimulation in ultrahigh-field magnetic resonance imaging (MRI). The patterns of connections revealed are similar to those of connections previously mapped with anatomical tract tracing methods. These include connections between cort...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau7046
更新日期:2019-04-24 00:00:00
abstract::Recent research on piezoelectric materials is predominantly devoted to enhancing the piezoelectric coefficient, but overlooks its sign, largely because almost all of them exhibit positive longitudinal piezoelectricity. The only experimentally known exception is ferroelectric polymer poly(vinylidene fluoride) and its c...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav3780
更新日期:2019-04-19 00:00:00
abstract::The process of sheep and goat (caprine) domestication began by 9000 to 8000 BCE in Southwest Asia. The early Neolithic site at Aşıklı Höyük in central Turkey preserves early archaeological evidence of this transformation, such as culling by age and sex and use of enclosures inside the settlement. People's strategies f...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw0038
更新日期:2019-04-17 00:00:00
abstract::Detection of amyloid-β (Aβ) aggregates contributes to the diagnosis of Alzheimer disease (AD). Plasma Aβ is deemed a less invasive and more accessible hallmark of AD, as Aβ can penetrate blood-brain barriers. However, correlations between biofluidic Aβ concentrations and AD progression has been tenuous. Here, we intro...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav1388
更新日期:2019-04-17 00:00:00
abstract::In traditional models of heteroepitaxy, the substrate serves mainly as a crystalline template for the thin-film lattice, dictating the initial roughness of the film and the degree of coherent strain. Here, performing in situ surface x-ray diffraction during the heteroepitaxial growth of LaTiO3 on SrTiO3 (001), we find...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav0764
更新日期:2019-04-12 00:00:00
abstract::NSF (N-ethylmaleimide-sensitive factor) and α-SNAP (α-soluble NSF attachment protein) bind to the SNARE (soluble NSF attachment protein receptor) complex, the minimum machinery to mediate membrane fusion, to form a 20S complex, which disassembles the SNARE complex for reuse. We report the cryo-EM structures of the α-S...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau8164
更新日期:2019-04-10 00:00:00
abstract::By experimentally studying high-order harmonic beams generated in gases, we show how the spatial characteristics of these ultrashort extreme-ultraviolet (XUV) beams can be finely controlled when a single fundamental beam generates harmonics in a thin gas medium. We demonstrate that these XUV beams can be emitted as co...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau7175
更新日期:2019-04-05 00:00:00
abstract::Variations in Earth's orbit pace the glacial-interglacial cycles of the Quaternary, but the mechanisms that transform regional and seasonal variations in solar insolation into glacial-interglacial cycles are still elusive. Here, we present transient simulations of coevolution of climate, ice sheets, and carbon cycle o...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav7337
更新日期:2019-04-03 00:00:00
abstract::Animals, humans, and multi-robot systems operate in dynamic environments, where the ability to respond to changing circumstances is paramount. An effective collective response requires suitable information transfer among agents and thus critically depends on the interaction network. To investigate the influence of the...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau0999
更新日期:2019-04-03 00:00:00
abstract::Surface plasmon resonance microscopy (SPRM) with single-direction illumination is a powerful platform for biomedical imaging because of its wide-field, label-free, and high-surface-sensitivity imaging capabilities. However, two disadvantages prevent wider use of SPRM. The first is its poor spatial resolution that can ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav5335
更新日期:2019-03-29 00:00:00
abstract::Iron deficiency and anemia are prominent contributors to the preventable disease burden worldwide. A substantial proportion of people with inadequate dietary iron rely on rice as a staple food, but fortification efforts are limited by low iron bioavailability. Furthermore, using high iron fortification dosages may not...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau0790
更新日期:2019-03-27 00:00:00
abstract::The urea channel of Helicobacterpylori (HpUreI) is an ideal drug target for preventing gastric cancer but incomplete understanding of its gating mechanism has hampered development of inhibitors for the eradication of H. pylori. Here, we present the cryo-EM structures of HpUreI in closed and open conformations, both at...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav8423
更新日期:2019-03-20 00:00:00
abstract::Earth's night sky continuously produces a faint chemiluminescence known as nightglow. Two prominent nighttime emissions around 90 km are the O2 Atmospheric and the OH Meinel band systems. Despite a plethora of studies since their identification seven decades ago, substantial gaps persist in our understanding of the me...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau9255
更新日期:2019-03-20 00:00:00
abstract::We studied a bilayer system hosting two-dimensional electron systems (2DESs) in close proximity but isolated from one another by a thin barrier. One 2DES has low electron density and forms a Wigner solid (WS) at high magnetic fields. The other has much higher density and, in the same field, exhibits fractional quantum...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aao2848
更新日期:2019-03-15 00:00:00
abstract::We tested how sediment trapping by hydroelectric dams affects tropical estuaries by comparing two dammed and two undammed rivers on Mexico's Pacific coast. We found that dams demonstrably affected the stability and productivity of the estuaries. The two rivers dammed for hydroelectricity had a rapid coastal recession ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau9875
更新日期:2019-03-13 00:00:00
abstract::In sickle cell disease, the aberrant assembly of hemoglobin fibers induces changes in red blood cell morphology and stiffness, which leads to downstream symptoms of the disease. Therefore, understanding of this assembly process will be important for the treatment of sickle cell disease. By performing the highest spati...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau1086
更新日期:2019-03-13 00:00:00
abstract::Under rapid high-temperature, high-pressure loading, lattices exhibit complex elastic-inelastic responses. The dynamics of these responses are challenging to measure experimentally because of high sample density and extremely small relevant spatial and temporal scales. Here, we use an x-ray free-electron laser providi...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau8044
更新日期:2019-03-08 00:00:00
abstract::The Late Paleogene surface height and paleoenvironment for the core area of the Qinghai-Tibetan Plateau (QTP) remain critically unresolved. Here, we report the discovery of the youngest well-preserved fossil palm leaves from Tibet. They were recovered from the Late Paleogene (Chattian), ca. 25.5 ± 0.5 million years, p...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav2189
更新日期:2019-03-06 00:00:00
abstract::Spin caloritronics has recently emerged from the combination of spintronics and thermoelectricity. Here, we show that flexible, macroscopic spin caloritronic devices based on large-area interconnected magnetic nanowire networks can be used to enable controlled Peltier cooling of macroscopic electronic components with ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav2782
更新日期:2019-03-01 00:00:00